![]() When we further explored the effects of this compound using other behavioral place preference assays, we found that AS1 was similarly able to reverse the negative hedonic valence of other painful (chemical) and non-painful (dark) aversive stimuli without being inherently rewarding. Resultsįrom our behavioral screen, we discovered a small molecule, Analgesic Screen 1 (AS1), which surprisingly elicited attraction to noxious painful heat. Here, we describe the screening of a small molecule library using a thermal place aversion assay in larval zebrafish to identify compounds that alter aversion to noxious thermal stimuli and could thus serve as potential analgesics. However, many existing analgesics are ineffective in treating chronic pain, while others (e.g., opioids) have undesirable side effects. ![]() Pain is the primary reason people seek medical care, with chronic pain affecting ~ 20% of people in the USA. ![]()
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